HIGH-GRADE ASTROCYTOMA IN AN ADULT: IMAGING FINDINGS AND HISTOPATHOLOGICAL CORRELATION. PRESENTATION OF A CLINICAL CASE
Keywords:
Astrocytoma, glioma, CNS tumorsAbstract
DOI: https://doi.org/10.46296/yc.v10i18.0892
Abstract
High-grade astrocytoma is an infiltrative glial neoplasm of the central nervous system characterized by aggressive behavior and progressive potential. Its diagnosis requires clinical correlation, imaging studies, histopathology, and molecular markers, especially within the current classification of CNS tumors. Magnetic resonance imaging plays a central role, as it allows assessment of lesion location, extension, edema, mass effect, contrast enhancement, and imaging features suggestive of tumor aggressiveness. Clinically, gliomas may be present with headache, focal neurological deficits, cognitive impairment, or seizures. Treatment is usually multimodal and includes surgical resection followed by radiotherapy and chemotherapy according to the histological and molecular profile. In addition, the tumor microenvironment and cellular interactions are important in tumor progression and represent potential future therapeutic targets.
Keywords: Astrocytoma, glioma, CNS tumors.
Downloads
References
Bailey P, Cushing H. A classification of the tumors of the glioma group on a histogenetic basis with a correlated study of prognosis. 1928.
Sevilla-Castillo RA, Andrade-Sarmiento LA. Factores asociados con supervivencia a cinco años en niños con astrocitoma cerebral. Gac Med Mex 2018;154. https://doi.org/10.24875/GMM.17003116.
Astudillo Mancero RD, Narváez Álvarez JE, Villagrán Herrero PA, et al. Astrocitoma, diagnóstico y tratamiento. RECIMUNDO 2021;5:53–64. https://doi.org/10.26820/recimundo/5.(4).oct.2021.53-64.
Louis DN, Perry A, Wesseling P, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol 2021;23:1231–51. https://doi.org/10.1093/neuonc/noab106.
Bianconi A, Aruta G, Rizzo F, et al. Systematic Review on Tumor Microenvironment in Glial Neoplasm: From Understanding Pathogenesis to Future Therapeutic Perspectives. Int J Mol Sci 2022;23:4166. https://doi.org/10.3390/ijms23084166.
Pérez Cruza GC, Molina Vegab ES, Colcha González RA. Astrocitoma fibrilar difuso. Recimundo 2019;3:853–75. https://doi.org/10.26820/recimundo/3.(3.Esp).noviembre.2019.853-875.
Gaillard F, Agazzi GM, Mazini B. Astrocytoma, IDH-mutant. Radiopaedia.org, Radiopaedia.org; 2011. https://doi.org/10.53347/rID-14598.
Rigsby RK, Brahmbhatt P, Desai AB, et al. Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation. American Journal of Neuroradiology 2023;44:367–80. https://doi.org/10.3174/ajnr.A7827.
Batool A, Azra Bashir, Saira Javed, et al. GRANULAR CELL ASTROCYTOMA. Journal of Ayub Medical College Abbottabad 2023;35:158–60. https://doi.org/10.55519/JAMC-01-10493.
Moreno-Jiménez S, Miranda-Fernández KA, García Gutiérrez M, et al. Astrocitoma y epilepsia. Caso clínico. Cir Cir 2017;85:419–23. https://doi.org/10.1016/j.circir.2016.05.009.
Published
How to Cite
License
Copyright (c) 2026 REVISTA CIENTÍFICA MULTIDISCIPLINARIA ARBITRADA YACHASUN - ISSN: 2697-3456
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
