SIMULTANEOUS DETERMINATION OF NON-STEROIDAL ANTI-INFLAMMATORIES IN WATER FOR HUMAN CONSUMPTION BY HPLC-DAD
Keywords:
Emerging pollutants; non-steroidal anti-inflammatory drugs; high performance liquid chromatography, diode array detectorAbstract
The growth of the urban population triggers a series of technical, ecological and social challenges to ensure the availability and quality of surface water due to the presence of emerging contaminants, which in recent years have aroused scientific interest due to their increasing presence in aqueous media. The objective of this study was the simultaneous determination of six non-steroidal anti-inflammatory drugs (aspirin, diclofenac, ibuprofen, keterolac, meloxicam and naproxen) by high performance liquid chromatography coupled to a diode array detector (HPLC-DAD). Different water sampling points were established along the Portoviejo River near drinking water catchment areas, as well as drinking water samples were collected in the cities of Manta, Portoviejo and Rocafuerte. Initial results revealed that the concentrations of these contaminants were found to be below the analytical technique detection and quantification limits, making impossible to quantify them at µg/L levels, both in surface water and drinking water samples. The results also suggest that more sensitive and accurate analytical techniques are needed for the evaluation of these contaminants to determine concentrations of these drugs at ng/L levels.
Keywords: Emerging pollutants; non-steroidal anti-inflammatory drugs; high performance liquid chromatography, diode array detector.
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