PERFUSIÓN POR TOMOGRAFÍA COMPUTARIZADA VERSUS RESONANCIA DIFUSIÓN-PERFUSIÓN EN ICTUS ISQUÉMICO TARDÍO

Autores/as

Palabras clave:

Accidente cerebrovascular isquémico, Perfusión por tomografía computarizada, Imagen por resonancia magnética, Trombectomía

Resumen

DOI: https://doi.org/10.46296/yc.v10i18.0855

Resumen

La neuroimagen avanzada amplió la selección de pacientes con ictus isquémico y oclusión de gran vaso más allá de las primeras seis horas. Esta revisión de tema comparó la perfusión por tomografía computarizada y la resonancia magnética con difusión y perfusión para la toma de decisiones entre seis y veinticuatro horas. Se revisaron PubMed, Scopus y Embase entre 2016 y 2025. Ambos métodos identifican núcleo isquémico y tejido recuperable con resultados clínicos semejantes cuando se aplican criterios validados. La perfusión por tomografía computarizada ofrece mayor disponibilidad, integración al flujo del código ictus y menor impacto logístico. La resonancia magnética con difusión y perfusión aporta mejor caracterización tisular y mayor capacidad para excluir imitadores, aunque con menor acceso y más contraindicaciones. La variabilidad entre programas de posprocesamiento y la heterogeneidad operativa siguen limitando la estandarización. En conclusión, ambas estrategias son válidas; la elección debe individualizarse según recursos, tiempos y contexto clínico.

Palabras claves: Accidente cerebrovascular isquémico, Perfusión por tomografía computarizada, Imagen por resonancia magnética, Trombectomía.

Abstract

Advanced neuroimaging expanded patient selection for acute ischemic stroke with large vessel occlusion beyond the first six hours. This review compared computed tomography perfusion and magnetic resonance imaging with diffusion and perfusion for decision making between six and twenty-four hours. PubMed, Scopus, and Embase were reviewed from 2016 to 2025. Both methods identify infarct core and potentially salvageable tissue with similar clinical results when validated criteria are applied. Computed tomography perfusion offers broader availability, easier integration into stroke workflow, and less logistical burden. Magnetic resonance imaging with diffusion and perfusion provides better tissue characterization and stronger exclusion of stroke mimics, although with lower access and more contraindications. Postprocessing software variability and operational heterogeneity still limit standardization. Overall, both strategies are valid, and the choice should be individualized according to resources, timing, and clinical context.

Keywords: Ischemic stroke, Computed tomography perfusion, Magnetic resonance imaging, Thrombectomy.

Información del manuscrito:
Fecha de recepción:
08 de enero de 2026.
Fecha de aceptación: 20 de marzo de 2026.
Fecha de publicación: 20 de abril de 2026.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2018;49(3):e46-e110.

Turc G, Bhogal P, Fischer U, Khatri P, Lobotesis K, Mazighi M, et al. European Stroke Organisation (ESO)-European Society for Minimally Invasive Neurological Therapy (ESMINT) guidelines on mechanical thrombectomy in acute ischemic stroke. J Neurointerv Surg. 2019;11(6):535-8.

Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med. 2018;378(1):11-21.

Albers GW, Marks MP, Kemp S, Christensen S, Tsai JP, Ortega-Gutierrez S, et al. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging. N Engl J Med. 2018;378(8):708-18.

Thomalla G, Simonsen CZ, Boutitie F, Andersen G, Berthezene Y, Cheng B, et al. MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. N Engl J Med. 2018;379(7):611-22.

Ma H, Campbell BCV, Parsons MW, Churilov L, Levi CR, Hsu C, et al. Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke. N Engl J Med. 2019;380(19):1795-803.

Jovin TG, Nogueira RG, Lansberg MG, Demchuk AM, Martins SO, Mocco J, et al. Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis. Lancet. 2022;399(10321):249-58.

Christensen S, Lansberg MG. CT perfusion in acute stroke: Practical guidance for implementation in clinical practice. J Cereb Blood Flow Metab. 2019;39(9):1664-8.

Campbell BCV, Parsons MW. Imaging selection for acute stroke intervention. Int J Stroke. 2018;13(6):554-67.

Nguyen TN, Abdalkader M, Nagel S, Qureshi MM, Ribo M, Caparros F, et al. Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion. JAMA Neurol. 2022;79(1):22-31.

Vagal A, Wintermark M, Nael K, Bivard A, Parsons M, Grossman AW, et al. Automated CT perfusion imaging for acute ischemic stroke: Pearls and pitfalls for real-world use. Neurology. 2019;93(20):888-98.

Suomalainen OP, Martinez-Majander N, Sibolt G, Backlund K, Jarvelainen J, Korvenoja A, et al. Comparative analysis of core and perfusion lesion volumes between commercially available computed tomography perfusion software. Eur Stroke J. 2023;8(1):259-67.

Lim NE, Chia B, Bulsara MK, Parsons M, Hankey GJ, Bivard A. Automated CT Perfusion Detection of the Acute Infarct Core in Ischemic Stroke: A Systematic Review and Meta-Analysis. Cerebrovasc Dis. 2023;52(1):97-109.

Bankole NDA, Mujanovic A, Dokponou YCH, Provost C, Pasi M, Redjem H, et al. MRI versus CT before endovascular thrombectomy in the early time window: A systematic review and meta-analysis. J Neuroradiol. 2025;52(6):101384.

Fainardi E, Busto G, Morotti A. Automated advanced imaging in acute ischemic stroke. Certainties and uncertainties. Eur J Radiol Open. 2023;11:100524.

Chen C, Parsons MW, Levi CR, Spratt NJ, Lin L, Kleinig T, et al. What Is the "Optimal" Target Mismatch Criteria for Acute Ischemic Stroke? Front Neurol. 2021;11:590766.

Kobeissi H, Ghozy S, Adusumilli G, Bilgin C, Tolba H, Amoukhteh M, et al. CT Perfusion vs Noncontrast CT for Late Window Stroke Thrombectomy: A Systematic Review and Meta-analysis. Neurology. 2023;100(22):e2304-e2311.

Diestro JDB, Omar AT 2nd, Zhang YQ, Kishibe T, Mastrolonardo A, Lannon MM, et al. Perfusion vs non-perfusion computed tomography imaging in the late window of emergent large vessel ischemic stroke: A systematic review and meta-analysis. PLoS One. 2024;19(1):e0294127.

Bobe RC, Coroiu RE, Cirstian AE, Cristescu CI, Pepelea DA, Manea RM. The Role of CT Perfusion in the Evaluation and Management of Acute Ischemic Stroke-A Systematic Review. Life (Basel). 2025;15(11):1693.

Thomalla G, Boutitie F, Ma H, Koga M, Ringleb P, Schwamm LH, et al. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. Lancet. 2020;396(10262):1574-84.

Campbell BCV, Ma H, Ringleb PA, Parsons MW, Churilov L, Bendszus M, et al. Extending thrombolysis to 4.5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data. Lancet. 2019;394(10193):139-47.

Mokin M, Ansari SA, McTaggart RA, Bulsara KR, Goyal M, Chen M, et al. Indications for thrombectomy in acute ischemic stroke from emergent large vessel occlusion (ELVO): report of the SNIS Standards and Guidelines Committee. J Neurointerv Surg. 2019;11(3):215-20.

Sarraj A, Hassan AE, Abraham MG, Ortega-Gutierrez S, Kasner SE, Hussain MS, et al. Trial of Endovascular Thrombectomy for Large Ischemic Strokes. N Engl J Med. 2023;388(14):1259-71.

Huo X, Ma G, Tong X, Zhang X, Pan Y, Nguyen TN, et al. Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct. N Engl J Med. 2023;388(14):1272-83.

Lin CH, Lee M, Ovbiagele B, Liebeskind DS, Sanz-Cuesta B, Saver JL. Endovascular thrombectomy in acute stroke with a large ischemic core: A systematic review and meta-analysis of randomized controlled trials. PLoS Med. 2025;22(4):e1004484.

Descargas

Publicado

2026-04-20

Cómo citar

Montiel-Lombana, G. P., Zambrano-Ortiz, D., Jaimes-Uribe, Y. A., Ordóñez-López, C. S., Romero-Paternina, D. A., Rúa-Pertuz, L. V. D., Gutierrez-Bravo, C. M., Torres-Gómez, J. I., Alvarez-Gonzalez, J. C., & Trujillo-García, D. A. (2026). PERFUSIÓN POR TOMOGRAFÍA COMPUTARIZADA VERSUS RESONANCIA DIFUSIÓN-PERFUSIÓN EN ICTUS ISQUÉMICO TARDÍO. REVISTA CIENTÍFICA MULTIDISCIPLINARIA ARBITRADA YACHASUN - ISSN: 2697-3456, 10(18), 1091–1110. Recuperado a partir de https://editorialibkn.com/index.php/Yachasun/article/view/925